Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus

Table 4

Demographic characteristics, neurologic examinations, and electrophysiologic studies of patients with or without DPNP^a.

Variables	No DPNP	DPNP
Patient no.	129	16
Gender (F/M)	48/81	6/10
Age (y)
BMI (kg/m^2)
Duration of T2DM (y)
HTN, (%)	5 (3.9)	2 (12.5)
HbA1C (%)
T-CHOL (mg/dl)
HDL-C (mg/dl)
LDL-C (mg/dl)
TG (mg/dl)
Vit. B12 (pg/ml)
Hom (μmol/l)
eGFR (ml/min/1.73m^2)
NCS score of neuropathy		2 ± 2
No. of abnormal NCS	51 (39.5)	11 (68.8)
mMNSI, total score
Symptoms of polyneuropathy	43 (33.3)	16 (100.0)
Reduction of ankle reflex	101 (78.3)	15 (93.8)
Bilateral median neuropathy at wrists	66 (51.2)	8 (50.0)
Abnormal thermal test	52 (40.3)	10 (62.5)
Abnormal vibration	24 (18.6)	6 (37.5)

Abbreviations: mMNSI: modified Michigan Neuropathy Screening Instrument; DSPN: distal symmetrical polyneuropathy; DPNP: diabetic peripheral neuropathic pain; NCS: nerve conduction studies; DN4: Douleur Neuropathique; F: females; M: males; y: years; BMI: body mass index; T2DM: type II diabetes mellitus; HTN: hypertension; HbA1C: glycated haemoglobin; Vit. B₁₂: vitamin B₁₂; HTN: hypertension; Hom: homocysteine; T-CHOL: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglyceride; eGFR: estimated glomerular filtration rate. ^aDPNP indicates patients with . Data were presented as of F/M for gender, (%) for categorical variables, and for continuous values by patients with and without DPNP. Data were compared using the chi-squared test for categorical variables and the two-sample -test for continuous ones. , , and indicate significant difference in comparing patients with and without DPNP.