Diabetic Distal Symmetrical Polyneuropathy: Correlation of Clinical, Laboratory, and Electrophysiologic Studies in Patients with Type 2 Diabetes Mellitus

Table 5

Demographic characteristics, neurologic examinations, and electrophysiologic studies for the symptomatic and asymptomatic^a patients.

Variables	Asymptomatic	Symptomatic
Patient no.	86	59
Gender (F/M)	33/53	21/38
Age (y)
BMI (kg/m^2)
Duration of T2DM (y)
HTN, (%)	4 (4.7)	3 (5.1)
HbA1C (%)
T-CHOL (mg/dl)
HDL-C (mg/dl)
LDL-C (mg/dl)
TG (mg/dl)
Vit. B12 (pg/ml)
Hom (μmol/l)
eGFR (ml/min/1.73m^2)
DPNP, (%)	0 (0.0)	16 (27.1)
mMNSI, total score
Symptoms of polyneuropathy	0 (0)	59 (100)
Reduction of ankle reflex	59 (68.6)	57 (96.6)
Bilateral median neuropathy at wrists	36 (41.9)	38 (64.4)
Abnormal thermal test	30 (34.9)	32 (54.2)
Abnormal vibration	8 (9.3)	22 (37.3)

Abbreviations: mMNSI: modified Michigan Neuropathy Screening Instrument; DSPN: distal symmetrical polyneuropathy; DPNP: diabetic peripheral neuropathic pain; NCS: nerve conduction studies; DN4: Douleur Neuropathique; F: females; M: males; y: years; BMI: body mass index; T2DM: type II diabetes mellitus; HTN: hypertension; HbA1C: glycated haemoglobin; Vit. B₁₂: vitamin B₁₂; HTN: hypertension; Hom: homocysteine; T-CHOL: total cholesterol; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; TG: triglyceride; eGFR: estimated glomerular filtration rate. ^aSymptomatic DSPN was defined as complaint of symmetrical, bilateral, distal sensory and/or motor defects. Data were presented as of F/M for gender, (%) for categorical variables, and for continuous values by the symptomatic and asymptomatic patients. Data were compared using the chi-squared test for categorical variables and the two-sample -test for continuous ones. , , and indicate significant difference when comparing the symptomatic and asymptomatic patients.