Exploring the Mechanism of Skeletal Muscle in a Tacrolimus-Induced Posttransplantation Diabetes Mellitus Model on Gene Expression Profiles

Table 4

Functional annotation of hub genes.

Gene ID	Gene name	Description
Tpm3	Tropomyosin alpha-3 chain	Binds to actin filaments in muscle and nonmuscle cells
Tnnc1	Troponin C type 1	Slow skeletal and cardiac muscles
Tnnt1	Troponin T1	The tropomyosin-binding subunit of troponin
Tnni3	Troponin I, cardiac muscle	The inhibitory subunit of troponin
Hrh3	Histamine Receptor H3	Increase voltage-dependent calcium current in smooth muscles
Apln	Apelin	Activate specific signaling pathways that regulate insulin secretion
S1pr3	Sphingosine-1-Phosphate Receptor 3	A G-protein-coupled receptor for the bioactive sphingosine-1-phosphate, which is an important regulator of skeletal muscle function
Cxcl12	C-X-C Motif Chemokine Ligand 12	Plays a protective role after myocardial infarction