Green <i>Coffea arabica</i> Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats

<div>Histopathological alterations of testicular tissue following green coffee water extract (50 and 100 mg kg<sup>-1</sup>) or metformin (200 mg kg<sup>-1</sup>) in high-fat diet/streptozotocin-induced diabetes in rats. Normal testicular architecture in the control and green coffee water extract including normal seminiferous tubule structure with normal spermatogenesis (a, b). In contrast, high-fat diet/streptozotocin diabetic rats exhibited fat droplets between the tubules (blue star) and degeneration of spermatogenic cells alongside vacuolated patches within the seminiferous tubules (red star) (c). However, pretreatment with metformin or green coffee water extract (50 and 100 mg kg<sup>-1</sup>) reversed the histological alterations in response to high-fat diet/streptozotocin diabetes (d–f). <span class="nowrap"><svg height="12.7373pt" id="M52" style="vertical-align:-3.429399pt" version="1.1" viewbox="-0.0498162 -9.3079 99.8059 12.7373" width="99.8059pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M409 504C401 567 396 607 392 642C354 654 312 665 266 665C137 665 60 583 60 487C60 374 161 325 225 290C300 250 355 215 355 141C355 68 311 21 235 21C131 21 86 122 71 183L41 176C48 128 61 42 68 21C78 16 93 8 118 0C142 -7 175 -15 216 -15C349 -15 438 69 438 174C438 287 344 333 265 374C186 414 138 449 138 522C138 576 172 631 249 631C336 631 363 562 380 499L409 504Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.345,0)"><path d="M390 111C344 68 312 56 269 56C212 56 118 102 118 241C118 346 175 401 241 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Journal of Diabetes Research

fig7

Figure 7

Figure 7: Green <i>Coffea arabica</i> Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats 

Journal of Diabetes Research

Green Coffea arabica Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats

Figure 7