Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus

Figure 3

Pathogenic role of NFAT5 in diabetes complications (isotonic/hypertonic NFAT5). β3-Adrenoreceptor gene (ADRB3), angiotensin- (Ang-) II, aquaporin- (AQP-) 5, cyclooxygenase- (COX-) 2, interferon- (IFN-) γ, interleukin- (IL-) 4, lipopolysaccharide (LPS), monocyte chemoattractant protein- (MCP-) 1, nuclear factor- (NF-) κB, nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3), platelet-derived growth factor- (PDGF-) BB, reactive oxygen species (ROS), regulatory (Treg) T cells, serum- and glucocorticoid-inducible kinase (SGK1), smooth muscle actin (SMA), tumor necrosis factor (TNF)-α, vascular endothelial growth factor (VEGF), and vascular smooth muscle cell (VSMC).