Journal of Diabetes Research

Research Article

Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the Confounding Effect of Antidiabetic Agents

Table 3

Difference of relative abundance phylum and genera between healthy and T2DM individuals and the influence of T2DM and antidiabetic agents on relative abundance microbiota.


	Gut microbiota	Study group		Diabetic subgroups
	Gut microbiota	T2DM ()	HC ()	MET ()	GLIM ()	NT ()

Phylum	Firmicutes	0.70538	0.62941	0.64357	0.73542	0.73715
	Bacteroidetes	0.11494	0.20621	0.10678	0.10833	0.12972
	Proteobacteria	0.00819	0.06955	0.00540	0.00976	0.00941^h
	Euryarchaeota	0.04487	0.02236	0.09897	0.03353	0.00211
	Actinobacteria	0.10489	0.05399	0.11575	0.09478	0.10415^h
	Fusobacteria	0.00645	0.00144	0.01157	0.00020	0.00758
	Elusimicrobia	0.00002	0.00284	0.00005	0.00002	0.00000^h
	Tenericutes	0.01000	0.01000	0.01000	0.01000	0.01000
	Cyanobacteria	0.00177	0.00011	0.00497	0.00008	0.00026
	Spirochaetes	0.00042	0.00389	0.00048^m	0.00077	0.00002

Genera	Subdoligranulum	0.04409	0.02359	0.01118	0.02393	0.09716
	Catenibacterium	0.02132	0.00218	0.00391	0.00561	0.05444
	Bacteroides	0.02639	0.02676	0.05596	0.00781	0.01539
	Succinivibrio	0.00129	0.03231	0.00026	0.00282	0.00078
	Methanobrevibacter	0.04482	0.02224	0.09894^m	0.03350	0.00202
	Faecalibacterium	0.03673	0.09919	0.01871^m	0.05300	0.03849^h
	Holdemanella	0.04082	0.01657	0.06683	0.02723	0.02839
	Bifidobacterium	0.08112	0.04477	0.09200	0.07046	0.08090
	Lactobacillus	0.03338	0.01825	0.03788	0.03943	0.02284
	Romboutsia	0.00463	0.00810	0.00604	0.00501	0.00284
	Unidentified-Ruminococcaceae	0.06293	0.04849	0.05558	0.06855	0.06467
	Unidentified-Christensenellaceae	0.00687	0.01057	0.01601	0.00389	0.00070
	Unidentified-Lachnospiraceae	0.02335	0.01694	0.02584	0.02489	0.01933
	Agathobacter	0.02619	0.02413	0.02003	0.02862	0.02992
	Fusobacterium	0.00383	0.00045	0.01135	0.00008	0.00005^h
	Unidentified-Clostridiales	0.01594	0.01028	0.01742	0.01372	0.01669
	Streptococcus	0.00999	0.00525	0.01164	0.00766	0.01067
	Blautia	0.02246	0.01521	0.02067	0.02684	0.01988
	Dialister	0.01113	0.02689	0.00712	0.01812	0.00815^h
	Roseburia	0.00817	0.01250	0.00726	0.00709	0.01015
	Elusimicrobium	0.00002	0.00284	0.00005	0.00002	0.00000^h
	Enterococcus	0.00273	0.00025	0.00026	0.00038	0.00756
	Dorea	0.01363	0.00885	0.01380	0.01649	0.01006
	Alloprevotella	0.00206	0.00685	0.00281	0.00060^g	0.00276
	Weissella	0.00243	0.00390	0.00098	0.00024	0.00606
	Unidentified-Cyanobacteria	0.00177	0.00011	0.00497	0.00008	0.00026
	Unidentified-Muribaculaceae	0.00001	0.00157	0.00003	0.00000	0.00000
	Megasphaera	0.00095	0.00271	0.00091	0.00123	0.00070
	Parabacteroides	0.00258	0.00531	0.00197	0.00114	0.00462
	Parvimonas	0.00148	0.00000	0.00434	0.00006	0.00003

At 95% level of significance, Mann-Whitney test (nonparametric data) and 2 independent-samples -test^a (parametric data) assessed the difference between groups. Data expressed as mean. A value of less than 0.05 was considered significant. , , and . The significant values were labeled by m, g, and h for the nontherapeutic subgroup (NT) versus metformin (MET), glimepiride (GLIM), and healthy control (HC), respectively. : number; T2DM: type 2 diabetes mellitus.