Journal of Diabetes Research / 2020 / Article / Tab 3

Research Article

Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the Confounding Effect of Antidiabetic Agents

Table 3

Difference of relative abundance phylum and genera between healthy and T2DM individuals and the influence of T2DM and antidiabetic agents on relative abundance microbiota.

Gut microbiotaStudy groupDiabetic subgroups
T2DM
()
HC
()
MET
()
GLIM
()
NT
()

PhylumFirmicutes0.705380.629410.643570.735420.73715
Bacteroidetes0.114940.206210.106780.108330.12972
Proteobacteria0.008190.069550.005400.009760.00941h
Euryarchaeota0.044870.022360.098970.033530.00211
Actinobacteria0.104890.053990.115750.094780.10415h
Fusobacteria0.006450.001440.011570.000200.00758
Elusimicrobia0.000020.002840.000050.000020.00000h
Tenericutes0.010000.010000.010000.010000.01000
Cyanobacteria0.001770.000110.004970.000080.00026
Spirochaetes0.000420.003890.00048m0.000770.00002

GeneraSubdoligranulum0.044090.023590.011180.023930.09716
Catenibacterium0.021320.002180.003910.005610.05444
Bacteroides0.026390.026760.055960.007810.01539
Succinivibrio0.001290.032310.000260.002820.00078
Methanobrevibacter0.044820.022240.09894m0.033500.00202
Faecalibacterium0.036730.099190.01871m0.053000.03849h
Holdemanella0.040820.016570.066830.027230.02839
Bifidobacterium0.081120.044770.092000.070460.08090
Lactobacillus0.033380.018250.037880.039430.02284
Romboutsia0.004630.008100.006040.005010.00284
Unidentified-Ruminococcaceae0.062930.048490.055580.068550.06467
Unidentified-Christensenellaceae0.006870.010570.016010.003890.00070
Unidentified-Lachnospiraceae0.023350.016940.025840.024890.01933
Agathobacter0.026190.024130.020030.028620.02992
Fusobacterium0.003830.000450.011350.000080.00005h
Unidentified-Clostridiales0.015940.010280.017420.013720.01669
Streptococcus0.009990.005250.011640.007660.01067
Blautia0.022460.015210.020670.026840.01988
Dialister0.011130.026890.007120.018120.00815h
Roseburia0.008170.012500.007260.007090.01015
Elusimicrobium0.000020.002840.000050.000020.00000h
Enterococcus0.002730.000250.000260.000380.00756
Dorea0.013630.008850.013800.016490.01006
Alloprevotella0.002060.006850.002810.00060g0.00276
Weissella0.002430.003900.000980.000240.00606
Unidentified-Cyanobacteria0.001770.000110.004970.000080.00026
Unidentified-Muribaculaceae0.000010.001570.000030.000000.00000
Megasphaera0.000950.002710.000910.001230.00070
Parabacteroides0.002580.005310.001970.001140.00462
Parvimonas0.001480.000000.004340.000060.00003

At 95% level of significance, Mann-Whitney test (nonparametric data) and 2 independent-samples -testa (parametric data) assessed the difference between groups. Data expressed as mean. A value of less than 0.05 was considered significant. , , and . The significant values were labeled by m, g, and h for the nontherapeutic subgroup (NT) versus metformin (MET), glimepiride (GLIM), and healthy control (HC), respectively. : number; T2DM: type 2 diabetes mellitus.

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