Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the Confounding Effect of Antidiabetic Agents
Table 4
Link of relative abundance microbiota and T2DM.
Gut microbiota
Duration of T2DM
Spearman correlation
1-5 years ()
6-10 years ()
Duration
FBG
HbA1c
Phylum
Firmicutes
0.68311
0.81671
0.062
-0.257
0.272
Bacteroidetes
0.12843
0.04749
0.072
0.250
-0.277
Proteobacteria
0.00714
0.01345
0.164
0.301
-0.183
Euryarchaeota
0.05367
0.00086
-0.454
-0.120
0.199
Actinobacteria
0.10364
0.11115
0.073
0.023
-0.412
Fusobacteria
0.00773
0.00004
-0.414
0.074
-0.156
Elusimicrobia
0.00003
0.00000
-0.166
0.047
0.009
Tenericutes
0.01000
0.01000
0.059
0.105
0.229
Cyanobacteria
0.00212
0.00004
-0.364
-0.270
0.418
Spirochaetes
0.00048
0.00013
-0.316
0.089
0.031
Genera
Subdoligranulum
0.01783
0.17537
0.064
-0.324
-0.108
Catenibacterium
0.00325
0.11168
0.064
-0.162
-0.342
Bacteroides
0.03069
0.00489
0.351
0.446
0.192
Succinivibrio
0.00094
0.00301
0.067
0.024
-0.315
Methanobrevibacter
0.05364
0.00071
-0.466
-0.127
0.175
Faecalibacterium
0.03720
0.03441
0.092
-0.870
-0.344
Holdemanella
0.03348
0.07751
-0.051
-0.217
0.006
Bifidobacterium
0.08066
0.08343
0.055
-0.038
-0.443
Lactobacillus
0.03249
0.03787
-0.086
-0.158
-0.464
Romboutsia
0.00546
0.00049
-0.190
0.203
0.262
Unidentified-Ruminococcaceae
0.06656
0.04480
-0.197
-0.043
0.432
Unidentified-Christensenellaceae
0.00821
0.00016
-0.306
-0.015
0.086
Unidentified-Lachnospiraceae
0.02428
0.01871
0.000
-0.227
-0.486
Agathobacter
0.02307
0.04179
0.125
-0.251
-0.320
Fusobacterium
0.00459
0.00002
0.132
0.376
-0.144
Unidentified-Clostridiales
0.01769
0.00721
-0.235
-0.037
0.112
Streptococcus
0.01119
0.00401
-0.110
-0.083
-0.282
Blautia
0.01937
0.03794
0.211
-0.020
-0.257
Dialister
0.01247
0.00442
-0.140
-0.108
-0.301
Roseburia
0.00852
0.00638
0.050
0.027
-0.199
Elusimicrobium
0.00003
0.00000
-0.166
0.047
0.009
Enterococcus
0.00026
0.01512
-0.082
-0.125
0.174
Dorea
0.01137
0.02493
0.094
-0.352
-0.430
Alloprevotella
0.00232
0.00071
-0.492
-0.020
0.195
Weissella
0.00281
0.00056
-0.185
0.180
0.030
Unidentified-Cyanobacteria
0.00212
0.00004
-0.364
-0.270
0.418
Unidentified-Muribaculaceae
0.00001
0.00000
-0.018
0.303
-0.002
Megasphaera
0.00094
0.00098
-0.255
-0.146
0.114
Parabacteroides
0.00246
0.00316
0.130
0.278
0.276
Parvimonas
0.00177
0.00001
-0.115
0.101
-0.239
The statistical difference between groups was assessed by Mann-Whitney test (nonparametric data) and 2 independent-samples -testa (parametric data). Data presented as mean. A value of less than 0.05 was considered significant. . FBG: fasting blood glucose; HbA1c: hemoglobin A1c; : number; T2DM: type 2 diabetes mellitus.
