Journal of Diabetes Research / 2020 / Article / Tab 4

Research Article

Alterations of Gut Microbiota in Type 2 Diabetes Individuals and the Confounding Effect of Antidiabetic Agents

Table 4

Link of relative abundance microbiota and T2DM.

Gut microbiotaDuration of T2DMSpearman correlation
1-5 years
()
6-10 years
()
DurationFBGHbA1c

PhylumFirmicutes0.683110.816710.062-0.2570.272
Bacteroidetes0.128430.047490.0720.250-0.277
Proteobacteria0.007140.013450.1640.301-0.183
Euryarchaeota0.053670.00086-0.454-0.1200.199
Actinobacteria0.103640.111150.0730.023-0.412
Fusobacteria0.007730.00004-0.4140.074-0.156
Elusimicrobia0.000030.00000-0.1660.0470.009
Tenericutes0.010000.010000.0590.1050.229
Cyanobacteria0.002120.00004-0.364-0.2700.418
Spirochaetes0.000480.00013-0.3160.0890.031

GeneraSubdoligranulum0.017830.175370.064-0.324-0.108
Catenibacterium0.003250.111680.064-0.162-0.342
Bacteroides0.030690.004890.3510.4460.192
Succinivibrio0.000940.003010.0670.024-0.315
Methanobrevibacter0.053640.00071-0.466-0.1270.175
Faecalibacterium0.037200.034410.092-0.870-0.344
Holdemanella0.033480.07751-0.051-0.2170.006
Bifidobacterium0.080660.083430.055-0.038-0.443
Lactobacillus0.032490.03787-0.086-0.158-0.464
Romboutsia0.005460.00049-0.1900.2030.262
Unidentified-Ruminococcaceae0.066560.04480-0.197-0.0430.432
Unidentified-Christensenellaceae0.008210.00016-0.306-0.0150.086
Unidentified-Lachnospiraceae0.024280.018710.000-0.227-0.486
Agathobacter0.023070.041790.125-0.251-0.320
Fusobacterium0.004590.000020.1320.376-0.144
Unidentified-Clostridiales0.017690.00721-0.235-0.0370.112
Streptococcus0.011190.00401-0.110-0.083-0.282
Blautia0.019370.037940.211-0.020-0.257
Dialister0.012470.00442-0.140-0.108-0.301
Roseburia0.008520.006380.0500.027-0.199
Elusimicrobium0.000030.00000-0.1660.0470.009
Enterococcus0.000260.01512-0.082-0.1250.174
Dorea0.011370.024930.094-0.352-0.430
Alloprevotella0.002320.00071-0.492-0.0200.195
Weissella0.002810.00056-0.1850.1800.030
Unidentified-Cyanobacteria0.002120.00004-0.364-0.2700.418
Unidentified-Muribaculaceae0.000010.00000-0.0180.303-0.002
Megasphaera0.000940.00098-0.255-0.1460.114
Parabacteroides0.002460.003160.1300.2780.276
Parvimonas0.001770.00001-0.1150.101-0.239

The statistical difference between groups was assessed by Mann-Whitney test (nonparametric data) and 2 independent-samples -testa (parametric data). Data presented as mean. A value of less than 0.05 was considered significant. . FBG: fasting blood glucose; HbA1c: hemoglobin A1c; : number; T2DM: type 2 diabetes mellitus.

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