Middle-Aged Indians with Type 2 Diabetes Are at Higher Risk of Biological Ageing with Special Reference to Serum CDKN2A
Table 1
Baseline characteristics of the study population according to age groups.
Variables
Group 1 (31-40 years)
Group 2 (41-50 years)
G1 controls ()
G1 T2DM ()
value
G2 controls ()
G2 T2DM ()
value
Age (years)
34 (31-36)
35.5 (33.25-39)
0.024
45 (42-48)
46 (43-48.75)
0.287
Body weight (kg)
65.95 (58.18-75.55)
71.05 (65.73-79.85)
0.054
64.25 (54.48-69.8)
66.45 (63-75)
0.011
Height (cm)
162 (157-171)
163.28 (156.25-170.75)
0.635a
158.5 (150.25-165.75)
163 (152.88-168.75)
0.295a
BMI (kg/m2)
24.91 (22.79-26.77)
27.11 (24.6-28.87)
0.002
26.13 (21.47-28.1)
27.23 (24.75-29.64)
0.082
WC (cm)
90.5 (86-93.75)
93 (84.63-102.38)
0.173
90.5 (83.38-94.5)
95 (91-99.5)
0.002
HC (cm)
97 (90.25-101.38)
101.2 (95-105)
0.009
98 (92.5-104.88)
100.5 (97.13-104.38)
0.170
WHR
0.929 (0.899-0.978)
0.915 (0.88-0.953)
0.138
0.927 (0.856-0.957)
0.956 (0.903-0.979)
0.021
SBP (mmHg)
116.5 (110.6-122.89)
124.5 (120-130)
<0.001a
116 (110-129.75)
125 (120-135)
0.001a
DBP (mmHg)
76.75 (72.63-80)
80 (77.88-81.75)
0.008
78 (71.5-81)
80 (80-84.75)
0.010
FPG (mmol/L)
4.59 (4.25-4.97)
7.5 (5.77-9.08)
<0.001
4.54 (4.23-4.9)
7.38 (6.26-10.77)
<0.001
FPI (μIU/mL)
13.1 (9.24-21.14)
25.26 (16.1-40.74)
<0.001
19.46 (10.66-28.97)
16.62 (12.44-28.27)
0.810
HOMA-IR
2.72 (1.9-3.96)
8.85 (5.17-14.59)
<0.001
4.08 (2.12-5.88)
5.22 (3.47-10.03)
0.003
HbA1c (%)
4.9 (4.7-5.18)
7.07 (6.7-8.3)
<0.001
4.97 (4.71-5.2)
8.32 (6.88-8.7)
<0.001
Duration of diabetes (years)
—
2.75 (1.5-5)
—
—
6.75 (3-10.88)
—
TG (mmol/L)
1.23 (0.94-1.57)
1.41 (0.97-2.37)
0.038
1.03 (0.86-1.41)
1.37 (1-1.82)
0.018
TC (mmol/L)
4.07 (3.45-4.52)
4.16 (3.32-5.18)
0.233a
4.21 (2.87-4.8)
3.76 (3.42-4.42)
0.662a
HDL-c (mmol/L)
1.05 (0.93-1.25)
0.91 (0.8-1.09)
0.004
0.96 (0.88-1.15)
0.95 (0.87-1.14)
0.866
LDL-c (mmol/L)
2.34 (1.87-2.84)
2.48 (1.7-3.03)
0.501
2.55 (1.45-3.18)
2.18 (1.67-2.58)
0.169
hs-CRP (mg/L)
3.65 (1.93-5.7)
6.35 (3.85-8.4)
0.001
4.4 (2.5-6.03)
4.72 (3.95-6.31)
0.095
CDKN2A (ng/mL)
3.346 (2.49-4.07)
3.589 (2.41-5.8)
0.137
3.184 (1.51-4.93)
7.5 (4.26-12.15)
<0.001
Data are represented as median and interquartile range (IQR); value using the Mann–Whitney test; a value using Independent -test (for normally distributed data); BMI: body mass index; WC: waist circumference; HC: hip circumference; WHR: waist-hip ratio; FPG: fasting plasma glucose; FPI: fasting plasma insulin; HbA1c: hemoglobin A1C; HOMA-IR: homeostatic model assessment-insulin resistance; TG: triglyceride; TC: total cholesterol; HDL-c: high-density lipoprotein cholesterol; LDL-c: low-density lipoprotein cholesterol; hs-CRP: high-sensitivity C-reactive protein; CDKN2A: cyclin-dependent kinase inhibitor 2A.
