Middle-Aged Indians with Type 2 Diabetes Are at Higher Risk of Biological Ageing with Special Reference to Serum CDKN2A
Table 3
Association of oxidative stress and proinflammatory cytokines with biological ageing marker CDKN2A among T2DM patients and controls using the Chi-square test.
Group
Markers
Level of markers
CDKN2A (>4.46 ng/mL)
, df
value
Low
High
Controls ()
MDA (>7.6 μmol/L)
Low
45 (77.6%)
15 (68.2%)
0.752, 1
0.386
High
13 (22.4%)
7 (31.8%)
oxLDL (>1.08 μg/mL)
Low
41 (70.7%)
19 (86.4%)
2.090, 1
0.148
High
17 (29.3%)
3 (13.6%)
IL-6 (>3.04 pg/mL)
Low
44 (75.9%)
19 (86.4%)
1.051, 1
0.305
High
14 (24.1%)
3 (13.6%)
IL-1β (>1.16 pg/mL)
Low
45 (77.6%)
15 (68.2%)
0.752, 1
0.386
High
13 (22.4%)
7 (31.8%)
TNF-α (>0.88 pg/mL)
Low
44 (75.9%)
16 (72.7%)
0.084, 1
0.772
High
14 (24.1%)
6 (27.3%)
MCP-1 (>77.3 pg/mL)
Low
46 (79.3%)
14 (63.6%)
2.090, 1
0.148
High
12 (20.7%)
8 (36.4%)
T2DM patients ()
MDA (>7.6 μmol/L)
Low
12 (36.4%)
23 (48.9%)
1.245, 1
0.264
High
21 (63.6%)
24 (51.1%)
oxLDL (>1.08 μg/mL)
Low
13 (39.4%)
28 (59.6%)
3.160, 1
0.075
High
20 (60.6%)
19 (40.4%)
IL-6 (>3.04 pg/mL)
Low
14 (42.4%)
8 (17%)
6.275, 1
0.012
High
19 (57.6%)
39 (83%)
IL-1β (>1.16 pg/mL)
Low
19 (57.6%)
21 (44.7%)
1.289, 1
0.256
High
14 (42.4%)
26 (55.3%)
TNF-α (>0.88 pg/mL)
Low
19 (57.6%)
13 (27.7%)
7.230, 1
0.007
High
14 (42.4%)
34 (72.3%)
MCP-1 (>77.3 pg/mL)
Low
22 (66.7%)
8 (17%)
20.388, 1
<0.001
High
11 (33.3%)
39 (83%)
: Chi-square value; df: degrees of freedom; value from the Chi-square test; each cell indicated count (% within age group); MDA: malondialdehyde; oxLDL: oxidized LDL; IL-6: interleukin-6; IL-1β: interleukin-1β; TNF-α: tumor necrosis factor α; MCP-1: monocyte chemoattractant protein-1; CDKN2A: cyclin-dependent kinase inhibitor 2A.
