Geranylgeranyl Transferase-I Knockout Inhibits Oxidative Injury of Vascular Smooth Muscle Cells and Attenuates Diabetes-Accelerated Atherosclerosis

Figure 2

Conditional knockout of VSMC GGTase-I attenuates diabetes-accelerated atherosclerosis. (a) Representative images of en face oil red O staining of aortas. (b) Quantification of oil red O positive areas in en face aortas. (c) Representative hematoxylin and eosin staining (HE) of cross-sectional aortas. (d) Quantification of lesion areas and media thickness from HE staining cross-sectional aortas. Data are expressed as , for each group. and versus strain-matched nondiabetic mice. ^# and ^## versus diabetic wild-type mice.

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