A Putative Prohibitin-Calcium Nexus in β-Cell Mitochondria and Diabetes

Table 1

PHB1 function	Location	Subcellular localization	Pathophysiology	Reference
Oxidative stress regulation	-Cells	Mitochondria	Type 2 diabetes	Lee et al., FEBBS J, 2010.
Oxidative stress regulation	Intestinal epithelial cells	Mitochondria	Inflammatory bowel disease	Kathiria e al., Plos One, 2010.
α-SMA regulation	Renal cells	Mitochondria	Tubulointerstitial lesions	Zhou et al., J of Recep and Signal Trans, 2013.
Oxidative stress regulation	Cardiomyocytes	Mitochondria	Myocardium damage	Liu et al., Cell Stress Chaperone, 2009.
Oxidative stress regulation	Hepatocytes	Mitochondria	HCV	Ivanov et al., Viruses, 2013.
Combating inflammation	Lungs	Mitochondria	COPD	Soulitzis et al., Resp. Med, 2012.
P-53, Rb tumor regulator	Cancer cells	Nucleus	Cancer	Fusaro et al., JBC, 2003.
Synaptic movement	Neural cells	Mitochondria/nucleus	Schizophrenia	Bemstein et al., Neuromol Med, 2012