Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China

Table 1

Baseline characteristics of individuals with type 2 diabetes (T2DM) and control subjects.

Characteristics	T2DM	Controls
Number	2220	3619
Age (years)
Men (%)	43.8	53.1
BMI (kg/m^2)
TC (mmol/L)
TG (mmol/L)
LDL-C (mmol/L)
HDL-C (mmol/L)
Apo-A (mmol/L)
Apo-B (mmol/L)
Drinker (%)	30.0	38.0
Smoker (%)	42.0	48.1
Hypertension (%)	76.4	66.7
Coronary heart disease (%)	28.9	27.5
No. of rs2237895 C alleles
0	39.5	46.4
1	46.5	42.7
2	14.0	10.9

BMI: body mass index; TC: total cholesterol; TG: triglyceride; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; Apo-A: apolipoprotein A; Apo-B: apolipoprotein B. Notes: continuous variables were reported as . Differences between cases and controls were analyzed using the paired -test and McNemar’s chi-squared test. All tests showed significant values ().