Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China

Table 2

Association between KCNQ1 rs2237895 and different lipid parameters and T2DM.

Variables	(SE)	PC (%) (95% CI)
Lipid parameters
TC	0.049 (0.021)	5.01 (0.80, 9.38)	0.019
TG	-0.018 (0.028)	-1.75 (-7.03, 3.82)	0.530
LDL-C	0.039 (0.016)	3.93 (0.64, 7.33)	0.019
HDL-C	0.015 (0.007)	1.51 (0.18, 2.86)	0.026
Apo-A	0.015 (0.007)	1.51 (0.04, 3.01)	0.045
Apo-B	0.015 (0.006)	1.51 (0.38, 2.66)	0.009
T2DM
Model 1	0.154 (0.028)	16.65 (10.43, 23.22)	<0.001
Model 2	0.163 (0.028)	17.64 (11.30, 24.35)	<0.001

: estimate; SE: standard error; PC: percentage change; CI: confidence interval; TC: total cholesterol; TG: triglyceride; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; Apo-A: apolipoprotein A; Apo-B: apolipoprotein B; T2DM: type 2 diabetes mellitus. Notes: models for lipid parameters and T2DM model 1 were adjusted for age, sex, smoking and drinking status, hypertension, coronary heart disease, and body mass index. T2DM model 2 was adjusted for age, sex, smoking and drinking status, hypertension, coronary heart disease, body mass index, TC, TG, LDL-C, and HDL-C. values < 0.05 are shown in bold.