Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China

Table 3

Mediation analysis of the association between the KCNQ1 rs2237895 and T2DM risk mediated by lipid parameters.

Variables	Direct effect OR (95% CI)	Indirect effect OR (95% CI)	Total effect OR (95% CI)	PM (%)
TC	1.04 (1.03, 1.07)	1.01 (1.00, 1.02)	1.05 (1.03, 1.06)	2.9
TG	1.05 (1.03, 1.06)	1.00 (0.99, 1.00)	1.05 (1.03, 1.06)	1.3
LDL-C	1.05 (1.03, 1.07)	1.01 (1.00, 1.02)	1.05 (1.03, 1.06)	2.3
HDL-C	1.05 (1.03, 1.06)	1.00 (0.99, 1.00)	1.05 (1.03, 1.06)	0
Apo-A	1.05 (1.03, 1.07)	0.99 (0.99, 1.00)	1.05 (1.03, 1.07)	0
Apo-B	1.05 (1.03, 1.07)	1.01 (1.00, 1.02)	1.05 (1.03, 1.07)	3.1

OR: odds ratio; CI: confidence interval; PM: proportion mediated; T2DM: type 2 diabetes mellitus; TC: total cholesterol; TG: triglyceride; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; Apo-A: apolipoprotein A; Apo-B: apolipoprotein B. Notes: all models were adjusted for age, sex, smoking and drinking status, hypertension, coronary heart disease, and body mass index. Lipid parameters with significant indirect effects are shown in bold.