Research Article

Radix Rehmanniae and Corni Fructus against Diabetic Nephropathy via AGE-RAGE Signaling Pathway

Table 2

Sixty-four DN-related targets of active compounds.

Uniprot IDsProtein nameGene name

P22303AcetylcholinesteraseACHE
P08588Beta-1 adrenergic receptorADRB1
Q15109Advanced glycosylation end product-specific receptorAGER
P15121Aldo-keto reductase family 1 member B1AKR1B1
P31749RAC-alpha serine/threonine-protein kinaseAKT1
P31751RAC-beta serine/threonine-protein kinaseAKT2
P10415Apoptosis regulator Bcl-2BCL2
P42574Caspase-3CASP3
P24385G1/S-specific cyclin-D1CCND1
P02452Collagen alpha-1(I) chainCOL1A1
P16220Cyclic AMP-responsive element-binding protein 1CREB1
P27487Dipeptidyl peptidase 4DPP4
P21728D(1A) dopamine receptorDRD1
P03372Estrogen receptorESR1
P00734ProthrombinF2
P48023Tumor necrosis factor ligand superfamily member 6FASLG
P09038Fibroblast growth factor 2FGF2
P09601Heme oxygenase 1HMOX1
P282235-Hydroxytryptamine receptor 2AHTR2A
P05362Intercellular adhesion molecule 1ICAM1
P01344Insulin-like growth factor IIIGF2
P01584Interleukin-1 betaIL1B
P05231Interleukin-6IL6
P05412Transcription factor AP-1JUN
P61626Lysozyme CLYZ
P28482Mitogen-activated protein kinase 1MAPK1
P27361Mitogen-activated protein kinase 3MAPK3
P45983Mitogen-activated protein kinase 8MAPK8
P03956Interstitial collagenaseMMP1
P09238Stromelysin-2MMP10
P0825372 kDa type IV collagenaseMMP2
P08254Stromelysin-1MMP3
P14780Matrix metalloproteinase-9MMP9
P42345Serine/threonine-protein kinase mTORmTOR
P35228Nitric oxide synthase type IINOS2
P29474Nitric oxide synthase type IIINOS3
Q9NPH5NADPH oxidase 4NOX4
P15559NAD(P)H dehydrogenase [quinone] 1NQO1
P04150GR (nuclear receptor subfamily 3 group C member 1)NR3C1
P08235Nuclear receptor subfamily 3, group C, member 2 variant 1NR3C2
P48736Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformPIK3CG
P27986Phosphatidylinositol 3-kinase regulatory subunit alphaPIK3R1
P00749Urokinase-type plasminogen activatorPLAU
P27169Serum paraoxonase/arylesterase 1PON1
P37231Peroxisome proliferator-activated receptor gammaPPARG
P05771Protein kinase C beta typePRKCB
Q05655Protein kinase C delta typePRKCD
P07477Trypsin-1PRSS1
P60484Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTENPTEN
P23219Prostaglandin G/H synthase 1PTGS1
P35354Prostaglandin G/H synthase 2PTGS2
P18031Tyrosine-protein phosphatase nonreceptor type 1PTPN1
P29350Tyrosine-protein phosphatase nonreceptor type 6PTPN6
Q04206Transcription factor p65RELA
P16581E-selectinSELE
P16109P-selectinSELP
P00441Superoxide dismutase (Cu-Zn)SOD1
P04179Superoxide dismutase (Mn)SOD2
Q9NYA1Sphingosine kinase 1SphK1
P40763Signal transducer and activator of transcription 3STAT3
P01137Transforming growth factor beta-1 proproteinTGFB1
P01375Tumor necrosis factorTNF
P04637Cellular tumor antigen p53TP53
P15692Vascular endothelial growth factor AVEGFA