Exendin-4 Improves Diabetic Kidney Disease in C57BL/6 Mice Independent of Brown Adipose Tissue Activation

Figure 1

Exendin-4 treatment improved metabolism in diabetic mice induced by high-fat diet (HFD) and STZ. The body weight (a), random blood glucose (b, d), and food intake (c) were recorded during the period of building the model of diabetic mice. The serum levels of TG (e), LDL (f), and HDL (g) were measured by ELISA. BAT-specific genes (h) were analyzed. for each group. , , and vs. control group; ^# and ^### vs. DM+Exc group; ^& and ^&&& vs. DM-Con group; ⁺ vs. DM+E4 group.

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