Research Article

Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes

Figure 4

Effect of diabetes and insulin treatment on peripheral neuropathy. (a) Development of thermal induced pain assessed by Hargreaves’ test during the treatment period, and (b) thermal induced pain assessed by Hargreaves’ test, (c) intraepidermal nerve fiber density (IENFD), and (d) motor nerve conductance velocity at study termination. Data are presented as mean and SD. and , significantly different from control. ++ and +++, significantly different from STZ-DIO high-insulin. Control, ; STZ-DIO vehicle, ; STZ-DIO low-insulin, ; STZ-DIO high-insulin, except in cases where indicated otherwise, A: ; B: ; C: .