Insulin Treatment Attenuates Small Nerve Fiber Damage in Rat Model of Type 2 Diabetes

Table 2

Influence of different metabolic parameters on nerve damage using analysis of covariance.

Response variable	Explanatory variable and covariates	Parameter estimate	Standard error	value
(a) Thermal induced pain	TG	-1.3	0.7	0.07
	Treatment group	—		0.18
(b) IENFD	HbA1c%	-1.4	0.4	<0.001
	TC	-0.7	0.3	0.04
	Treatment group	—		0.7

The response variables (a) thermal induced pain and (b) intraepidermal nerve fiber density (IENFD) were evaluated in an analysis of covariance using stepwise backwards reduction leaving only significant covariates with group as class variable and HbA_1c%, sciatic nerve sorbitol content, triglyceride (TG), and total cholesterol (TC) as covariates to investigate the influence of the covariates on nerve damage. Only significant findings are shown. Log transformed.