Sex-Specific Association of Serum Uric Acid Level and Change in Hyperuricemia Status with Risk of Type 2 Diabetes Mellitus: A Large Cohort Study in China
Table 1
Baseline characteristics of the study population according to baseline serum uric acid quartile by sex.
Baseline characteristics
SUA quartiles
Q1 ()
Q2 ()
Q3 ()
Q4 ()
Men
SUA range (mg/dL)
≤5.42
5.42-6.20
6.20-7.05
>7.05
5,282
5,333
5,296
5,295
Age (years)
44.03 (12.83)
42.9 (12.62)
42.89 (12.91)
42.59 (12.67)
<0.001
Heart rate (beats/min)
75.02 (9.9)
75.21 (9.65)
75.43 (9.72)
76.35 (10.37)
<0.001
BMI (kg/m2)
24.78 (3.13)
25.5 (3.13)
26.22 (3.06)
27.12 (3.16)
<0.001
Height (cm)
171.45 (5.76)
172.06 (5.7)
172.27 (5.77)
172.51 (5.84)
<0.001
Weight (kg)
72.88 (10.19)
75.58 (10.46)
77.89 (10.37)
80.82 (10.99)
<0.001
WC (cm)
86.21 (8.42)
88.01 (8.53)
89.82 (8.11)
92.21 (8.35)
<0.001
Blood pressure (mmHg)
Systolic
121.24 (15.21)
121.54 (14.9)
123.07 (14.57)
124.54 (14.63)
<0.001
Diastolic
75.64 (10.25)
76.59 (9.74)
77.53 (9.95)
79.19 (9.95)
<0.001
SUA (mg/dL)
4.81 (0.52)
5.84 (0.22)
6.63 (0.24)
7.98 (0.79)
<0.001
FPG (mmol/L)
5.27 (0.52)
5.28 (0.51)
5.33 (0.51)
5.37 (0.53)
<0.001
TC (mmol/L)
4.72 (0.87)
4.81 (0.89)
4.92 (0.91)
5.08 (0.95)
<0.001
TG (mmol/L)
1.47 (1.15)
1.67 (1.25)
1.88 (1.37)
2.32 (1.79)
<0.001
HDL-C (mmol/L)
1.32 (0.29)
1.27 (0.27)
1.24 (0.26)
1.21 (0.26)
<0.001
LDL-C (mmol/L)
2.92 (0.72)
2.99 (0.74)
3.08 (0.73)
3.15 (0.77)
<0.001
eGFR (mL/min/1.73 m2)
97.49 (19.05)
93.96 (17.45)
91.91 (16.81)
88.94 (16.53)
<0.001
White blood cell
ALT (IU/L)
20.00 (15.00-27.00)
22.00 (16.80-30.10)
23.40 (17.70-34.00)
28.00 (19.93-40.10)
<0.001
Women
SUA range (mg/dL)
≤3.77
3.77-4.37
4.37-5.05
>5.05
4,080
3,966
4,030
4,014
Age (years)
37.79 (9.78)
38.3 (10.71)
39.67 (12.05)
43.58 (14.04)
Heart rate (beats/min)
76.8 (9.9)
76.63 (10)
76.28 (9.75)
76.02 (9.82)
<0.001
BMI (kg/m2)
22.28 (2.87)
22.78 (3.09)
23.46 (3.34)
24.98 (3.72)
<0.001
Height (cm)
160.48 (5.23)
160.82 (5.33)
160.72 (5.37)
160.22 (5.46)
<0.001
Weight (kg)
57.36 (7.74)
58.9 (8.21)
60.55 (8.8)
64.08 (9.94)
<0.001
WC (cm)
72.68 (7.22)
74.17 (7.7)
75.85 (8.35)
79.75 (9.19)
<0.001
Blood pressure (mmHg)
Systolic
110.21 (14.02)
110.77 (14.74)
112.08 (15.06)
116.89 (16.1)
<0.001
Diastolic
68.43 (9.05)
69.41 (9.53)
70.25 (9.65)
73.16 (9.92)
<0.001
SUA (mg/L)
3.35 (0.35)
4.09 (0.17)
4.69 (0.19)
5.78 (0.67)
<0.001
FPG (mmol/L)
5.01 (0.42)
5.04 (0.44)
5.08 (0.46)
5.2 (0.52)
<0.001
TC (mmol/L)
4.5 (0.85)
4.6 (0.87)
4.75 (0.9)
5.02 (0.97)
<0.001
TG (mmol/L)
0.94 (0.55)
1.02 (0.65)
1.13 (0.72)
1.43 (0.92)
<0.001
HDL-C (mmol/L)
1.58 (0.34)
1.55 (0.34)
1.51 (0.33)
1.44 (0.32)
<0.001
LDL-C (mmol/L)
2.6 (0.68)
2.7 (0.7)
2.82 (0.74)
3.07 (0.79)
<0.001
eGFR (mL/min/1.73 m2)
113.28 (24.91)
107.47 (23.54)
103.33 (23.11)
97.5 (22.36)
<0.001
White blood cell
ALT (IU/L)
13.00 (10.08-16.90)
13.20 (11.00-17.70)
14.00 (11.00-19.00)
17.00 (12.70-23.60)
<0.001
Abbreviations: BMI: body mass index; WC: waist circumference; SUA: serum uric acid; FPG: fasting plasma glucose; TC: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; eGFR: estimated glomerular filtration rate; ALT: alanine aminotransferase. Data are mean (SD) and median (interquartile range). Quartiles 1-4: ≤5.44, >5.44~≤6.22, >6.22~≤7.08, and >7.08 mg/dL for men and ≤3.80, >3.77~≤4.38, >4.38~≤5.05, and >5.05 mg/dL for women.
