Effects of Exenatide and Humalog Mix25 on Fat Distribution, Insulin Sensitivity, and β-Cell Function in Normal BMI Patients with Type 2 Diabetes and Visceral Adiposity

Table 2

Clinical, biochemical, and imaging parameters of normal BMI patients with T2DM and visceral adiposity before and after exenatide or humalog Mix25 intervention.

Variable	Pre-exenatide	Post-exenatide	value	Pre-humalog Mix25	Post-humalog Mix25	value
	()	()		()	()
BMI (kg/m^2)			<0.01	23.89 (22.65-24.46)	23.12 (21.48-23.95)	<0.01
Weight (kg)			<0.01			<0.01
WC (cm)			<0.01			<0.01
SBP (mmHg)	121.5 (117.5-136)	128 (117-135.5)	0.87			0.17
DBP (mmHg)	78 (75-84)	76 (70-81.5)	0.10			0.01
FPG (mmol/L)			0.01			<0.01
2hPBG (mmol/L)			0.039			0.47
FINS (mIU/L)			0.56			0.49
HbA1c (%)			<0.01			<0.01
TC (mmol/L)			0.26			0.82
TG (mmol/L)	1.35 (0.84-2.12)	1.26 (0.81-1.69)	0.13	1.46 (0.79-2.01)	1.09 (0.77-1.6)	0.01
AST (IU/L)	21 (18-25)	22 (18-27)	0.28			0.88
ALT (IU/L)	20 (16.5-34.5)	22 (16-30.5)	0.43	22 (18-26)	19 (17-24)	0.13
Creatinine (μmol/L)			0.52	53 (44-63)	60 (49-66)	<0.01
FGF-21 (pg/mL)			<0.01			0.21
SAT (cm^2)			<0.01			0.69
VAT (cm^2)			<0.01	76.36 (60.26-96.91)	71 (50.24-88.14)	<0.01
LFC (%)			<0.01			<0.01
HOMA-IR			<0.01			0.11
HOMA-β			0.63			0.37
IGI			0.33	3.77 (1.25-6.08)	4.27 (1.47-6.81)	0.58
Matsuda			0.15	4.54 (3.15-6.01)	4.58 (3-7.63)	0.78
MBCI			0.045	4.64 (3.39-6.77)	4.04 (2.83-7.38)	0.56
HOMA-ISHOMA-β			0.01			0.71
MatsudaMBCI						0.09

ALT: glutamic pyruvic transaminase; AST: glutamic oxalacetic transaminase; BMI: body mass index; DBP: diastolic blood pressure; FGF-21: fibroblast growth factor 21; FINS: fasting insulin; FPG: fasting plasma glucose; HbA1c: glycated haemoglobin; HOMA-β: homeostasis model assessment of β-cell function; HOMA-IR: homeostatic model assessment of insulin resistance; LFC: liver fat content; MBCI: modified β-cell function; SAT: subcutaneous and visceral adipose tissue; SBP: systolic blood pressure; TC: total cholesterol; TG: triglycerides; VAT: visceral adipose tissue; WC: waist circumference; 2hFBG: 2 h plasma blood glucose. Data are expressed as the or median (interquartile range).