Review Article
The Impact of Incretin-Based Medications on Lipid Metabolism
Table 2
The impact of incretin-based medications on lipid metabolism.
| Lipid metabolism | Effects of incretin-based therapy | Ref. | Clinical evidence |
| Lipogenesis and lipolysis | Reduces lipogenesis mainly thru an AMPK-dependent pathway | [57ā61, 63, 74] | [63, 70, 107, 108] | Lipid peroxidation | Inhibits lipid peroxidation and reduces lipotoxicity | [21, 80ā82, 84] | [88] | Fatty acid oxidation | Induces and promotes fatty acid oxidation | [49, 95] | [93] | Cholesterol synthesis | Inhibits HMG-CoA reductase and cholesterol biosynthesis, reduces atheroma plaque formation | [98, 100, 101] | [102] | Lipid absorption | Commonly reduces intestinal lipid absorption | [103, 104] | [105] |
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