Silver Nanoparticles Conjugate Attenuates Highly Active Antiretroviral Therapy-Induced Hippocampal Nissl Substance and Cognitive Deficits in Diabetic Rats

Figure 9

(a) Hippocampus CA1 Nissl staining histology (×400). A = nondiabetic control showing distinct pyramidal cells with well-stained Nissl bodies. B = nondiabetic+HAART showing pyramidal cells with mildly stained Nissl bodies. C = nondiabetic+HAART-AgNPs showing pyramidal cells with distinct stained Nissl bodies. D = diabetic control showing necrotic pyramidal cells with poorly stained Nissl bodies. E = diabetic+HAART showing pyramidal cells with mildly stained Nissl bodies and vacuolated neurons. F = diabetic+HAART-AgNPs showing pyramidal cells with distinct stained Nissl bodies. (b) Population of Nissl-stained neurons in the hippocampal CA1. Data are expressed as (); vs. group A (nondiabetic control), ^& vs. group D (diabetic control); ^$ vs. group E (diabetic+HAART).

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