Review Article
Impact of Incretin-Based Therapies on Adipokines and Adiponectin
Table 2
current knowledge on effects of incretin-based antidiabetic drugs on adipokines and adipocyte-derived cytokines.
| Adipocyte-derived cytokine | Effects of incretin-based drugs | Ref. |
| Leptin | Increase active levels of leptin and potentiate its metabolic effects | [38–44] | Ghrelin | Unknown clear interactions may potentiate metabolic impacts of ghrelin | [37, 52–55] | Visfatin | Induce visfatin expression/secretion | [74, 75] | Reduce active levels of visfatin | [46, 71–73] | Resistin | Decrease resistin activities | [47, 73, 89–91] | Increase resistin and related impacts | [68, 75] | Apelin | Induce apelin release | [103] | Adiponectin | Increase active levels of adiponectines to enhance insulin sensitivity | [32, 43, 90, 115, 116] |
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