Impact of Incretin-Based Therapies on Adipokines and Adiponectin

Table 2

current knowledge on effects of incretin-based antidiabetic drugs on adipokines and adipocyte-derived cytokines.

Adipocyte-derived cytokine	Effects of incretin-based drugs	Ref.
Leptin	Increase active levels of leptin and potentiate its metabolic effects	[38–44]
Ghrelin	Unknown clear interactions may potentiate metabolic impacts of ghrelin	[37, 52–55]
Visfatin	Induce visfatin expression/secretion	[74, 75]
	Reduce active levels of visfatin	[46, 71–73]
Resistin	Decrease resistin activities	[47, 73, 89–91]
	Increase resistin and related impacts	[68, 75]
Apelin	Induce apelin release	[103]
Adiponectin	Increase active levels of adiponectines to enhance insulin sensitivity	[32, 43, 90, 115, 116]