Differential HLA Association of GAD65 and IA2 Autoantibodies in North Indian Type 1 Diabetes Patients
Table 3
Association of the HLA-DQB1 alleles and HLA-DQB1 genotypes with GADA and IA2A in 252 T1D patients.
GADA
IA2A
Positives (%GF) ()
Negatives (%GF) ()
OR (95% CI)
value
Positives (%GF) ()
Negatives (%GF) ()
OR (95% CI)
value
DQB1 allele
02
121 (94.53)
91 (73.39)
6.27 (2.7-14.49)
4.39 × 10−6
2.19 × 10−5
33 (82.5)
179 (84.43)
0.87 (0.36-2.08)
0.943
03
48 (37.5)
45 (36.29)
1.05 (0.63-1.75)
0.945
21 (52.5)
72 (33.96)
2.15 (1.09-4.22)
0.04
0.20
04
0 (0)
2 (1.61)
0 (0-1.86)
0.464
0 (0)
2 (0.94)
0 (0-10.35)
1
05
10 (7.81)
35 (28.23)
0.21 (0.1-0.45)
2.34 × 10−5
1.17 × 10−4
5 (12.5)
40 (18.87)
0.61 (0.23-1.62)
0.46
06
15 (11.71)
32 (25.81)
0.38 (0.2-0.74)
0.007
0.035
6 (15.0)
41 (19.34)
0.74 (0.3-1.83)
0.671
DQB1/DQB1 genotype
02/02
45 (35.16)
28 (22.58)
1.86 (1.07-3.23)
0.028
0.168
10 (25)
63 (29.72)
0.79 (0.37-1.69)
0.679
02/03
42 (32.81)
31 (25)
1.47 (0.85-2.53)
0.219
19 (47.5)
54 (25.47)
2.65 (1.33-5.26)
0.009
0.054
02/XX
34 (26.56)
32 (25.81)
1.04 (0.6-1.82)
1
4 (10)
62 (29.25)
0.27 (0.1-0.76)
0.019
0.114
03/03
2 (1.56)
3 (2.42)
0.64 (0.13-3.27)
0.971
0 (0)
5 (2.36)
0 (0-4.09)
0.717
03/XX
4 (3.12)
11 (8.87)
0.33 (0.11-1.02)
0.097
2 (5)
13 (6.13)
0.81 (0.2-3.35)
1
XX/XX
1 (0.78)
19 (15.32)
0.04 (0.01-0.26)
1.96 × 10−5
1.18 × 10−4
5 (12.5)
15 (7.08)
1.88 (0.67-5.31)
0.398
Abbreviations: GF: gene/genotype frequency; CI: confidence interval; OR: odds ratio; : Bonferroni-corrected value; NA: not available; X: an allele other than DRB103 and 04. Statistically significant values are given in italic.
