Differential HLA Association of GAD65 and IA2 Autoantibodies in North Indian Type 1 Diabetes Patients

Table 4

Comparative distribution of T1D-associated HLA-DRB1-DQB1 haplotypes and their association with the presence or absence of GADA and IA-2A in 252 T1D patients.

DRB1-DQB1 haplotype	GADA				IA2A
	Positives (%HF); ()	Negatives (%HF); ()	OR (95% CI)	value	Positives (%HF); ()	Negatives (%HF); ()	OR (95% CI)	value
DRB103-DQB102	155 (60.55)	104 (41.94)	2.13 (1.49-3.03)	3.94 × 10^−5	39 (48.75)	220 (51.89)	0.88 (0.55-1.42)	0.694
DRB115-DQB106	11 (4.30)	24 (9.68)	0.42 (0.20-0.86)	0.028	3 (3.75)	32 (7.55)	0.49 (0.16-1.56)	0.357
DRB111-DQB103	1 (0.39)	8 (3.23)	0.12 (0.02-0.73)	0.039	1 (1.25)	8 (1.89)	0.66 (0.11-4.13)	1
DRB104-DQB103	41 (16.02)	32 (12.90)	1.29 (0.78-2.11)	0.387	18 (22.5)	55 (12.97)	1.95 (1.08-3.52)	0.041
DRB113-DQB106	4 (1.56)	10 (4.03)	0.38 (0.12-1.16)	0.157	3 (3.75)	11 (2.59)	1.46 (0.43-5.00)	0.837
DRB107-DQB102	11 (4.30)	15 (6.05)	0.70 (0.32-1.52)	0.492	4 (5.0)	22 (5.19)	0.96 (0.34-2.75)	1

Abbreviations: : diploid; HF: haplotype frequency; CI: confidence interval; OR: odds ratio. Significant values are italicized.