Association of Phthalate Exposure with Thyroid Function and Thyroid Homeostasis Parameters in Type 2 Diabetes
Table 4
Association between four major components determined by factor analysis and thyroid function and thyroid autoimmunity and thyroid homeostasis in multifactor models.
(a)
TSH
FT3
FT4
T3
T4
(95% CI)
(95% CI)
(95% CI)
(95% CI)
(95% CI)
Factor 1
-0.056 (-0.107, -0.004)
0.034
0.010 (-0.036, 0.056)
0.670
-0.051 (-0.233, 0.132)
0.586
0.014 (-0.009, 0.037)
0.225
0.575 (-0.885, 2.036)
0.440
Factor 2
0.189 (-0.044, 0.422)
0.111
-0.033 (-0.240, 0.174)
0.753
-0.190 (-1.019, 0.638)
0.652
-0.058 (-0.161, 0.046)
0.276
-3.196 (-9.820, 3.428)
0.344
Factor 3
-0.026 (-0.073, 0.020)
0.269
0.019 (-0.023, 0.060)
0.371
0.045 (-0.121, 0.211)
0.592
0.011 (-0.009, 0.032)
0.284
0.507 (-0.818, 1.833)
0.453
Factor 4
0.001 (-0.002, 0.010)
0.202
-0.004 (-0.046, 0.038)
0.863
-0.056 (-0.224, 0.122)
0.512
0.004 (-0.017, 0.025)
0.710
-0.506 (-1.848, 0.836)
0.459
(b)
SPINA-GD
SPINA-GT
TSHI
TTSI
(95% CI)
(95% CI)
(95% CI)
(95% CI)
Factor 1
0.209 (-0.051, 0.469)
0.115
0.043 (0.007, 0.079)
0.018
-0.062 (-0.114, -0.011)
0.017
-0.060 (-0.110, -0.010)
0.019
Factor 2
-0.424 (-1.603, 0.756)
0.481
-0.144 (-0.306, 0.018)
0.082
0.163 (-0.068, 0.395)
0.166
0.177 (-0.050, 0.404)
0.126
Factor 3
0.083 (-0.153, 0.319)
0.489
0.022 (-0.010, 0.055)
0.180
-0.020 (-0.066, 0.026)
0.393
-0.024 (-0.069, 0.022)
0.309
Factor 4
0.122 (-0.117, 0.362)
0.315
-0.007 (-0.040, 0.026)
0.684
-0.006 (-0.053, 0.041)
0.795
-0.002 (-0.048, 0.044)
0.920
Adjusted for age, sex, BMI, smoking status, and urine iodine to creatinine ratio and Factors 1, 2, 3, and 4. Factor 1 was highly loaded with MECPP, MEHHP, MEOHP, MCMHP, and MiNP. Factor 2 was highly loaded with MiBP, MnBP, and MEHP. Factor 3 was highly loaded with MCPP and MCHP, and Factor 4 was highly loaded with MBzP.
