Research Article
Impact of PCSK9 Immunization on Glycemic Indices in Diabetic Rats
Figure 4
The levels of fasting blood glucose (FBG) in the vaccinated STZ-injected (VS), diabetic control (DC), and normal control (NC) rats during the week after STZ injection. Data are represented as the . indicates compared to both the VS and NC groups (a). Oral glucose tolerance test (OGTT) (b) and corresponding areas under the glucose curve (AUCglucose) over 180 min (c) following feeding (2 g/kg) of the vaccinated STZ-injected (VS), diabetic control (DC), and normal control (NC) rats with oral glucose. Data are represented as the . The mean values of AUCglucose in the VS and DC groups showed a significant difference () compared to the NC group. When compared to the DC group, the mean values of AUCglucose in the VS group were significantly () different. The insulin tolerance test (ITT) (d) and corresponding areas under the glucose curve (AUCglucose) over 120 min (e) following insulin administration (0.8 U/kg) in the vaccinated STZ-injected (VS), diabetic control (DC), and normal control (NC) rats. Data are represented as the . The mean values of AUCglucose in the VS and DC groups showed a significant difference () compared to the NC group. When compared to the DC group, the mean values of blood glucose levels and AUCglucose in the VS group were significantly () lower.
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