Integrated Bioinformatics-Based Identification of Potential Diagnostic Biomarkers Associated with Diabetic Foot Ulcer Development

Table 1

Functional and pathway enrichment analyses for module genes. The top 3 terms were selected based upon value rankings when >3 terms were enriched for a given category.

A, biological processes
Term	Name	Count	value	Genes
GO:0045214	Sarcomere organization	7	1.3E-9	FHOD3, MYH3, ACTN2, CASQ2, CAPN3, LDB3, CASQ1
GO:0030049	Muscle filament sliding	4	4.4E-4	MYH3, ACTN2, MYL3, DMD
GO:1903779	Regulation of cardiac conduction	4	1.4E-3	PLN, CASQ2, ATP2B2, CASQ1
B, molecular functions
Term	Name	Count	value	Genes
GO:0008307	Structural constituent of muscle	9	4.8E-12	MYOM1, PDLIM3, ACTN2, MYOT, MYL3, CAPN3, NEXN, DMD, MYOM2
GO:0005515	Protein binding	50	5.9E-4	FHOD3, MYOM1, BTG1, LGALSL, LDB3, SAT1, N4BP2L2, HK2,; MYOM2, MED14, JPH2, XPO4, RASSF5, CAPN3, KIF1B, CTSC,; ACTN2, IGFBP3, MYH1, PPP1R3C, MYOT, PRR16, CASQ2, TKT, FKBP3, CAMK2B, USP54, MGST1, THBS1, GTF2E2, PDLIM3, UGP2, PLN,; CMYA5, KCNN2, DMD, PPARGC1A, S100A11, MPZL2, LGI1, MYH7B,; DTNA, FAM46C, AGL, DDIT4L, ATP2B2, PPP2R3A, EFNA1, PKIA, CUTC
GO:0005509	Calcium ion binding	10	2.2E-3	ACTN2, MYL3, CASQ2, CAPN3, ATP2B2, PPP2R3A, CASQ1, THBS1, PLCD4, S100A11
C, cellular component
Term	Name	Count	value	Genes
GO:0030018	Z disc	11	2.5E-11	FHOD3, JPH2, PDLIM3, ACTN2, MYOT, CASQ2, CAPN3, NEXN, LDB3, KCNN2, DMD
GO:0032982	Myosin filament	4	2.9E-5	MYH1, MYH7B, MYH3, MYOM2
GO:0031430	M band	4	9.1E-5	MYOM1, CMYA5, MYOM2, MYOM3
D, KEGG pathway
Term	Name	Count	value	Genes
hsa04261	Adrenergic signaling in cardiomyocytes	5	4.5E-3	CAMK2B, PLN, MYL3, ATP2B2, PPP2R3A
Hsa05414	Dilated cardiomyopathy	4	8.0E-3	PLN, SGCD, MYL3, DMD
hsa04530	Tight junction	4	8.8E-3	MYH1, MYH7B, MYH3, ACTN2
KEGG: Kyoto Encyclopedia of Genes and Genomes.