Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment

Figure 4

Representative pathological images by HE and Masson staining at 16 weeks: (a, b) HE staining; (c, d) Masson staining. The WT-DN group showed the disappearance of the normal tubular back-to-back structure with focal interstitial fibrosis compared to WT-control. The KO-DN group showed more severe tubulointerstitial fibrosis than that in the WT-DN group. (b, d) (200x) magnifications of the box in (a, c) (100x). per group. Abbreviations: HE: hematoxylin and eosin.