Adenosine A1 Receptor Deficiency Aggravates Extracellular Matrix Accumulation in Diabetic Nephropathy through Disturbance of Peritubular Microenvironment

Figure 6

A1AR deletion aggravated interstitial collagen deposition, interstitial fibrosis, and activation of PDGFRβ in DN mice. (a–f) The expression of collagen I, collagen III, collagen IV, PDGFRβ, TGFβ, and α-SMA by semiquantitative analysis of immunohistochemical staining. Compared to the WT-control group, the WT-DN group showed increased expression of all markers, while the increase was more overt in the KO-DN group. per group. Data was shown as the . The WT-control vs. the WT-DN: and ; WT-DN vs. KO-DN: ^# and ^##. Original .