Review Article
Optical Coherence Tomography Angiography of Macular Perfusion Changes after Anti-VEGF Therapy for Diabetic Macular Edema: A Systematic Review
Table 3
Study design, methods, and results of studies that found conflicting effects following treatment.
| Study | No. of eyes | Design of study | Imaging modality | Agent used and treatment duration | Outcome measure | Study results | Ref. |
| Busch et al. | 23 eyes of 23 patients with DME | Retrospective case series | OCTA (Optovue) scan using machine software for VD | Aflibercept (1-8 monthly injections) | Change in built-in machine VD and FAZ | SCP FAZ increased by 0.07 mm2 and DCP FAZ decreased by 0.04 mm2 () | [45] | Dastiridou et al. | 20 eyes of 20 patients with DME | Prospective case series | Swept source OCTA (Topcon) and scans | Aflibercept (3 injections) | Change in FAZ area and VD | FAZ of DCP and VD of central area decreased () | [46] |
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DCP: deep capillary plexus; DME: diabetic macular edema; FAZ: foveal avascular zone; OCTA: optical coherence tomography angiography; SCP: superficial capillary plexus; VD: vascular density.
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