Risk of Gestational Diabetes Mellitus in relation to Plasma Concentrations of Fatty Acid-Binding Protein 4: A Nested Case-Control Study in China

Table 3

Odds ratios of GDM by FABP4 levels in the first and second trimesters.

	Number of case (%)	Adjusted OR (95% CI)^†	Adjusted OR (95% CI)^‡
Tertiles of FABP4 in the first trimester (range, ng/L)
T1 (<35.8)	43 (47.8)	ref	ref
T2 (35.8~61.6)	38 (42.2)	0.798 (0.442-1.440)	0.866 (0.469-1.596)
T3 (>61.6)	54 (60.0)	1.607 (0.884-2.920)	2.053 (1.091-3.863)
for trend		0.045	0.008
Per 1 log increment		2.272 (0.974-5.452)	2.895 (1.157-7.249)
Tertiles of FABP4 in the second trimester (range, ng/L)
T1 (<37.9)	35 (38.9)	ref	ref
T2 (37.9~62.0)	48 (53.3)	1.772 (0.974-3.224)	1.970 (1.049-3.698)
T3 (>62.0)	52 (57.8)	2.134 (1.168-3.898)	2.447 (1.305-4.588)
for trend		0.032	0.015
Per 1 log increment		3.084 (1.199-7.930)	3.575 (1.343-9.517)

^†Adjusted for maternal age, gestational week at enrollment, and education. ^‡Further adjusted for prepregnancy body mass index, gestational weight gain before oral glucose tolerance test, physical activity, daily calorie intake, systolic blood pressure, diastolic blood pressure, triglyceride, high-density lipoprotein cholesterol, alanine transaminase, and aspartate aminotransferase. Abbreviations: GDM: gestational diabetes mellitus; FABP4: fatty acid-binding protein 4.