Associations between Vascular Endothelial Growth Factor Gene Polymorphisms and Different Types of Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis

Table 3

Meta-analysis of the associations between VEGF SNPs and NPDR.

SNPs	Number of study	Sample size		Dominant model				Recessive model				Allelic model
		Case	Control	OR (95% CI)	^2 (%)			OR (95% CI)	(%)			OR (95% CI)	(%)
rs2010963
Total	9	959	1357	1.25 (1.01-1.54)	45.3	0.067	0.039	1.58 (1.20-2.09)	37.5	0.119	0.001	1.26 (1.02-1.56)	50.6	0.040	0.031
Asian	7	872	1262	1.29 (1.04-1.60)	44.5	0.094	0.023	1.48 (1.11-1.99)	11.5	0.342	0.009	1.26 (1.08-1.47)	43.5	0.101	0.003
Caucasian	2	87	95	0.73 (0.18-3.04)	60.5	0.112	0.534	—	76.7	0.038	—	—	82.1	0.018	—
rs1570360
Total (Asian)	4	559	927	0.80 (0.59-1.09)	0.0	0.515	0.158	0.72 (0.47-1.12)	0.0	0.714	0.142	0.80 (0.63-1.01)	0.0	0.395	0.062
rs699947
Total	2	138	208	2.04 (1.30-3.21)	7.5	0.298	0.002	1.36 (0.54-3.44)	39.4	0.199	0.519	1.50 (0.81-2.79)	62.4	0.103	0.199

SNPs, single nucleotide polymorphisms; , Higgins I² statistic; , value for heterogeneity test; , value for the test; OR, odds ratio; CI, confidence interval; −, not available. ORs were calculated in random-effect model.