Associations between Vascular Endothelial Growth Factor Gene Polymorphisms and Different Types of Diabetic Retinopathy Susceptibility: A Systematic Review and Meta-Analysis
Table 4
Meta-analysis of the associations between VEGF SNPs and PDR.
SNPs
Number of study
Sample size
Dominant model
Recessive model
Allelic model
Case
Control
OR (95% CI)
(%)
OR (95% CI)
(%)
OR (95% CI)
(%)
rs2010963
Total
12
1431
2126
1.20 (1.03-1.41)
17.6
0.271
0.022
1.66 (1.21-2.28)
50.7
0.022
0.002
1.23 (1.11-1.37)
49.0
0.028
<0.001
Asian
8
964
1554
1.17 (0.97-1.43)
43.7
0.087
0.108
1.57 (1.04-2.35)
54.7
0.030
0.030
1.26 (1.01-1.57)
58.9
0.017
0.039
Caucasian
4
467
572
1.27 (0.96-1.67)
0.0
0.872
0.090
1.83 (1.28-2.63)
42.4
0.157
0.001
1.31 (1.09-1.57)
23.9
0.268
0.004
rs833061
Total
5
759
1093
1.41 (0.94-2.11)
50.7
0.088
0.094
1.49 (1.09-2.04)
27.5
0.238
0.013
1.33 (1.11-1.58)
46.3
0.114
0.002
Asian
4
677
1032
1.40 (0.90-2.17)
62.0
0.048
0.138
1.58 (1.11-2.26)
41.1
0.165
0.012
1.34 (0.99-1.81)
58.4
0.066
0.056
Caucasian
1
82
61
2.07 (0.34-12.78)
—
—
0.434
1.21 (0.62-2.37)
—
—
0.585
1.18 (0.71-1.96)
—
—
0.524
rs699947
Total
3
366
500
1.67 (1.27-2.21)
26.1
0.259
<0.001
1.32 (0.78-2.23)
31.8
0.231
0.304
1.44 (1.16-1.78)
0.0
0.481
0.001
Asian
2
322
426
1.72 (1.05-2.84)
62.4
0.103
0.033
1.50 (0.87-2.60)
0.0
0.342
0.145
1.48 (1.17-1.88)
0.0
0.328
0.001
Caucasian
1
44
74
1.82 (0.81-4.09)
—
—
0.148
0.18 (0.01-3.35)
—
—
0.248
1.19 (0.68-2.07)
—
—
0.537
SNPs, single nucleotide polymorphisms; , Higgins statistic; , value for heterogeneity test; value for the Z test; OR, odds ratio; CI, confidence interval; −, not available. ORs were calculated in random-effect model.
