Characteristics Associated with Early Worsening of Retinopathy in Patients with Type 2 Diabetes Diagnosed with Retinopathy at Their First Visit: A Retrospective Observational Study

Table 2

Univariate logistic regression analysis for retinopathy progression in patients with simple diabetic retinopathy.

	OR	95% CI	value	AUC	Cutoff value
Age (+1 years)	0.95	0.90–1.00	0.09
Sex (males)	5.03	0.92–94	0.13
Diabetes duration (+1 years)	0.93	0.85–0.99	0.05
Body mass index (+1 kg/m^2)	0.92	0.79–1.06	0.28
Newly diagnosed diabetes (yes)	1.48	0.30–5.72	0.59
New intervention (nonsulfonylurea vs. none)	4.17	0.50–26.8	0.16
New intervention (sulfonylurea vs. none)	5.21	1.25–21.7	0.02^*
New intervention (insulin vs. none)	3.70	0.81–15.8	0.09
Therapy intensification (yes)	4.37	1.47–14.2	0.01^*
Use of statins (yes)	0.73	0.19–2.35	0.62
Use of antihypertensive agents (yes)	0.29	0.08–0.86	0.03^*
Baseline HbA1c (+1%)	1.44	1.10–1.94	0.01^*	0.73	9.8
3 M HbA1c (+1%)	1.51	0.92–2.54	0.10
6 M HbA1c (+1%)	1.25	0.75–2.07	0.39
12 M HbA1c (+1%)	0.90	0.49–1.60	0.74
Δ3 M HbA1c (−1%)	1.34	1.00–1.82	0.05	0.71	−1.6
Δ6 M HbA1c (−1%)	1.31	1.00–1.74	0.048^*	0.69	−1.5
Δ12 M HbA1c (−1%)	1.38	1.06–1.83	0.02^*	0.75	−1.6
Δ12 M-Δ3 M HbA1c (−1%)	2.04	1.12–4.30	0.03^*	0.67	−0.6
Δ12 M-Δ6 M HbA1c (−1%)	2.96	1.34–6.96	0.01^*	0.73	−0.4
Baseline systolic blood pressure (mmHg)	0.99	0.96–1.02	0.61
Baseline diastolic blood pressure (mmHg)	1.01	0.97–1.05	0.60
Baseline triglyceride (mg/dL)	1.00	0.99–1.00	0.16
Baseline total cholesterol (mg/dL)	1.00	0.99–1.01	0.57
Baseline high density lipoprotein (mg/dL)	0.99	0.95–1.03	0.70
Baseline low density lipoprotein (mg/dL)	1.01	0.99–1.03	0.25
Baseline non-high-density lipoprotein (mg/dL)	1.00	0.98–1.01	0.61
Creatinine (mg/dL)	0.27	0.02–2.28	0.30
Uric acid (mg/dL)	0.91	0.57–1.42	0.67
Urinary albumin/creatinine ratio (mg/gCre)	1.00	0.99–1.00	0.91

^*.