Combination of GLP-1 Receptor Activation and Glucagon Blockage Promotes Pancreatic β-Cell Regeneration In Situ in Type 1 Diabetic Mice

Figure 4

Pancreatic histological analysis of α- to β-cell transdifferentiation in T1D mice treated with liraglutide, GCGR mAb, or both for four weeks. (a) Representative images of insulin and glucagon colocalization. (b) Representative images of insulin and tracing marker, red fluorescence protein (RFP), colocalization in pancreatic α-cell-tracing T1D mice. (c) Quantification of the glucagon⁺insulin⁺ cells. (d) Quantification of the RFP⁺insulin⁺ cells. Data are expressed as the . sections/mouse multiplied by 6 mice/group. Statistical analysis was conducted by ANOVA or Student’s -test when appropriate. ^# vs. STZ group; ^§ vs. liraglutide group. Magnified views of box regions are shown in the upper right panels.

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