Pathophysiology of Physical Inactivity-Dependent Insulin Resistance: A Theoretical Mechanistic Review Emphasizing Clinical Evidence

Figure 1

Simple schematic pic of insulin signal transduction (IRSs = insulin receptor substrates; PI3K = phosphoinositide 3-kinase; PIP2 = phosphatidylinositol 4,5-bisphosphate; PIP3 = phosphatidylinositol 3,4,5-trisphosphate; Akt = protein kinase B; Glut-4 = glucose transporter type 4).