Ellipsoid Zone Integrity and Visual Acuity Changes during Diabetic Macular Edema Therapy: A Longitudinal Study
Table 1
Demographics and characteristics for patients with 5-year data () compared to patients with only 3 years of follow-up ().
Baseline variables
With 5-year data ()
Only 3-year data ()
Mean (SD)
Median (Q1; Q3)
Mean (SD)
Median (Q1; Q3)
Age (years)
57.54 (8.04)
57.00 (51.00; 63.00)
61.67 (8.80)
63.00 (54.00; 68.00)
0.051°
HbA1c (%)
7.19 (1.27)
6.95 (6.49; 7.88)
7.40 (0.96)
7.37 (6.76; 7.60)
0.886°
VA in logMAR at baseline
0.39 (0.29)
0.30 (0.15; 0.59)
0.42 (0.37)
0.37 (0.10; 0.58)
0.799°
Pooled EZ-RPE reflectivity ratio (arbitrary unit)
0.69 (0.17)
0.70 (0.59; 0.81)
0.67 (0.16)
0.68 (0.59; 0.81)
0.756°
Pooled EZ-RPE distance (in pixel)
11.24 (1.53)
11.04 (9.89; 12.27)
11.33 (3.43)
10,81 (10.07; 11.63)
0.475°
Central retina thickness (in μm)
409.86 (133.22)
367.00 (312.00; 470.00)
419.30 (121.96)
370.50 (321.75; 489.75)
0.600°
Central macular volume (in μm3)
10.55 (2.19)
9.93 (9.18; 11.53)
10.50 (1.70)
10.39 (9.10; 11.20)
0.756°
(%)
(%)
Male sex
26 (70.30)
19 (55.90)
0.229†
Laser treatment before treatment
15 (40.54)
9 (26.47)
0.315†
Pseudophakia before treatment
7 (18.91)
12 (35.29)
0.180†
Variables during observation
Received dexamethasone implants
1.51 (2.90)
0.00 (0.00; 2.00)
1.62 (2.13)
0.50 (0.00; 3.00)
0.444°
Injections per year
5.11 (1.67)
5.08 (3.83; 6.20)
5.83 (1.75)
5.70 (4.27; 6.94)
0.777°
Injections in first year
4.97 (2.35)
5 (3.00; 6.00)
7.00 (2.88)
6.00 (5.00; 10.00)
0.004°
logMAR: logarithm of the minimum angle of resolution; p-EZR: pooled relative ellipsoid zone reflectivity; c-EZR: central relative ellipsoid zone reflectivity; EZ: ellipsoid zone; RPE: retinal pigment epithelium; SD: standard deviation; Q1: first quartile; Q3: third quartile. values from °Mann–Whitney test and †Pearson’s chi2 test. Values in italic front style denote statistical significance at the level.
