Effect of Metformin on Anthropometric Measurements and Hormonal and Biochemical Profile in Patients with Prediabetes

Table 2

The effect of metformin on metabolic profile in prediabetic participants.

Variable	Baseline	After 12 months	Adjusted value (GLM)
	Weight (kg)
Female			<0.001
Male			0.279
Body mass index (BMI)
Female			0.001
Male			0.253
Waist circumference (cm)
Female			0.001
Male			0.290
Fasting blood sugar (mg/dl)
Female			0.017
Male			0.300
Hemoglobin A1c
Female			0.001
Male			0.041
Insulin
Female			0.038
Male			0.366
Quantitative Sensitivity Check (QUICKI)
Female			0.062
Male			0.730
Homeostasis model assessment (HOMA)
Female			0.092
Male			0.606
Total cholesterol
Female	192.7 ± 44.2	183.9 ± 42.4	0.182
Male	196.1 ± 19.2	186.3 ± 46.1	0.028
Low density lipoprotein cholesterol (mg/dl)
Female			0.157
Male			0.306
High-density lipoprotein cholesterol (mg/dl)
Female			<0.001
Male			0.077
Triglyceride (mg/dl)
Female			0.124
Male			0.569

The changes in anthropometric variables are adjusted for age, and the changes in other variables are adjusted for age and waist circumference at the baseline. GLM: general linear model repeated measures analysis.