Effect of Metformin on Anthropometric Measurements and Hormonal and Biochemical Profile in Patients with Prediabetes

Table 4

Effect of metformin on pituitary and sex hormones in menopausal and nonmenopausal prediabetic ().

	Not menopausal			Menopausal
	Baseline,	After 12 months,	value	Baseline,	After 12 months,	value
Prolactin			0.033			0.043
Luteinizing hormone (LH)			0.455	28.5 ± 18.0	34.8 ± 22.7	0.022
Follicle-stimulating hormone (FSH)	6.2 ± 3.3	8.1 ± 4.7	0.022	58.8 ± 35.2	65.3 ± 33.0	0.008
Free testosterone	1.3 ± 0.6	1.2 ± 0.5	0.271	1.2 ± 0.4	1.3 ± 0.6	0.537
Total testosterone	0.5 ± 0.2	0.42 ± 0.1	0.032	0.5 ± 0.4	0.47 ± 0.6	0.101
Estradiol			0.491			0.505
Progesterone			0.548			0.303
Sex hormone-binding globulin (SHBG)			0.892			0.214
17-OH progesterone		1.8 ± 1.4	0.484			0.201
Androstendione			0.859			0.529
Dehydroepiandrostenedione-sulphate (DHEAS)			0.015			0.005