Relationship between Hyponatremia and Peripheral Neuropathy in Patients with Diabetes

Figure 2

Relationship between serum sodium level and diabetic peripheral neuropathy. Restricted cubic splines were used to flexibly model and visualize the relationship between the serum sodium level and DPN. The risk of DPN was relatively flat until around 140 mmol/L of the serum sodium level and then started to increase rapidly forward and afterward ( for nonlinearity <0.05) in all serum sodium groups, especially in male patients, those aged <65 years, and those with . However, a nonlinear trend was not observed in normal serum sodium group and its subgroups. The average serum sodium level of 140 mmol/L serves as a reference.