Relationship between Hyponatremia and Peripheral Neuropathy in Patients with Diabetes
Table 2
Nerve conduction velocity and nerve conduction amplitude of the different serum sodium groups.
Serum sodium (mmol/L)
value
value for trend analysis
Hyponatremia 130.0–135.0 ()
Low-normal sodium 135.0–141.5 ()
Medium-normal sodium 141.5–143.0 ()
High-normal sodium 143.0–145.00 ()
Hypernatremia 145.0–150.0 ()
Linear term
Quadratic term
Median-nerve MCV (m/s)
a
a
ab
0.001
<0.001
NC
Ulnar-nerve MCV (m/s)
a
ab
ab
ab
<0.001
<0.001
NC
Tibial-nerve MCV (m/s)
a
ab
ab
b
<0.001
<0.001
NC
Peroneal-nerve MCV (m/s)
a
b
ab
ab
<0.001
<0.001
NC
Median-nerve SCV (m/s)
a
a
a
a
0.002
<0.001
NC
Ulnar-nerve SCV (m/s)
a
a
ab
ab
<0.001
<0.001
NC
Superficial-nerve SCV (m/s)
a
a
ab
a
<0.001
0.027
NC
Sural-nerve SCV (m/s)
a
a
a
a
<0.001
<0.001
NC
Median-nerve CMAP (mv)
0.339
NC
NC
Ulnar-nerve CMAP (mv)
0.450
NC
NC
Tibial-nerve CMAP (mv)
a
a
a
a
0.020
NC
0.002
Peroneal-nerve CMAP (mv)
a
a
a
a
<0.001
NC
<0.001
Median-nerve SNAP (μv)
0.121
NC
NC
Ulnar-nerve SNAP (μv)
a
a
a
ab
0.001
0.001
NC
Superficial-nerve SNAP (μv)
a
a
a
a
0.034
NC
0.040
Sural-nerve SNAP (μv)
a
a
a
a
0.013
0.005
NC
CMAP: compound muscle action potential; MCV: motor nerve conduction velocity; SCV: sensory nerve conduction velocity; SNAP: sensory nerve action potential. Post hoc analysis: acompared with the hyponatremia group, ;bcompared with the low-normal sodium group, ;ccompared with the medium-normal sodium group, ;dcompared with the high-normal sodium group, . NC: nonconformance.
