Clinical and Genetic Characteristics of ABCC8 Nonneonatal Diabetes Mellitus: A Systematic Review

Figure 1

A schematic of the transmembrane topology of SUR1 showing the location of the variants both in ABCC8-NDM and ABCC8-NNDM. The transmembrane domains (TMD) include TMD0, TMD1, and TMD2. The nucleotide-binding domains (NBD) are indicated by NBD1 and NBD2, and the cytosolic linker L0 is between TMD0 and TMD1. ABCC8-NDM: ABCC8-induced neonatal diabetes mellitus; ABCC8-NNDM: ABCC8-induced nonneonatal diabetes mellitus.