Exosomes Secreted by Umbilical Cord Blood-Derived Mesenchymal Stem Cell Attenuate Diabetes in Mice

Figure 7

Intravenous post-MSC and Exo treatments increase cell proliferation and insulin level in the MSC and MSC-Exo-treated group. (a) Representative histological images of pancreatic tissue stained with BrdU showing increased BrdU-positive cells in diabetic animals treated with MSC or MSC-Exo in comparison with PBS-treated animals. Scale bar = 100 μM. (b) Histogram representing the percentage of BrdU-positive cells in MSC and MSC-Exo-treated diabetic animals in comparison with the PBS-treated group. (c) Histogram representing increased insulin level in pancreatic tissue of diabetic animals treated with MSC and MSC-Exo in comparison with PBS-treated animals. Data are shown as the (/group). The significance of differences between mean values was estimated by nonparametric Student’s -test (unpaired, two-tailed). and compared to the PBS-treated group.

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