Research Article
Islet Transplantation Reverses Podocyte Injury in Diabetic Nephropathy or Induced by High Glucose via Inhibiting RhoA/ROCK/NF-κB Signaling Pathway
Figure 6
Effects of islet cells and fasudil on synaptopodin, RhoA/ROCK1and pp65 proteins of podocyte in high glucose (35.0 mmol/L glucose) environment. (a, b) The effects of islet cells (islet cells were cocultured with podocytes) on synaptopodin protein and their semiquantitative analysis. (c–e) The effects of islet cells on proteins of RhoA/ROCK1 signaling pathway and their semiquantitative analysis. (f, g) The effects of islet cells and fasudil on pp65 protein and their semiquantitative analysis. versus the control group (5.5 mM glucose), # versus the HG (35 mM) alone. Coculture group: islet cells were cocultured with podocytes.
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