Application and Clinical Effectiveness of Antibiotic-Loaded Bone Cement to Promote Soft Tissue Granulation in the Treatment of Neuropathic Diabetic Foot Ulcers Complicated by Osteomyelitis: A Randomized Controlled Trial

Figure 2

Schematic drawing of the antibiotic-loaded bone cement procedure. (a) Dermal defect. (b) Antibiotic-loaded bone cement. (c) Antibiotic-loaded bone cement was implanted into the defect site, and release of the antibiotic. (d) Fibroblast and vascular endothelial cells grow into the scaffolds from the wound base and surrounding tissues, forming a new capillary cell complex. (e) After 3 weeks, the bone cement has degraded from the initial size, leaving only a remaining coat at the wound surface, covering a good granulated soft tissue. (f) The defect tissue was regenerated, living option for sutures or split thickness skin coverage of the wound.

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