Network Pharmacology and Molecular Docking Study on the Potential Mechanism of Yi-Qi-Huo-Xue-Tong-Luo Formula in Treating Diabetic Peripheral Neuropathy

Figure 7

Pathway map of YQHXTLF in the treatment of DPN. AGE/RAGE signaling causes activation of multiple intracellular signaling pathways involving NADPH oxidase, protein kinase C (PKC), and MAPKs and promotes the expression of multiple proinflammatory cytokines, leading to segmental demyelination of peripheral neurons.